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Target
Ceramide glucosyltransferase
Ligand
BDBM576427
Substrate
n/a
Meas. Tech.
UDP-Glo Glucosylceramide Synthase Biochemical Assay
EC50
260±n/a nM
Citation
 J., BM; E., FM; Marie, LH; J., MJ; J., RA; M., SK; J., SS MODIFIED ISOINDOLINONES AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS WIPO 0:0 (2022) [PubMed] 
Target
Name:
Ceramide glucosyltransferase
Synonyms:
CEGT_HUMAN | GCS | GLCT-1 | Glucosylceramide synthase | UDP-glucose ceramide glucosyltransferase | UDP-glucose:N-acylsphingosine D-glucosyltransferase | UGCG
Type:
PROTEIN
Mol. Mass.:
44859.25
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1435474
Residue:
394
Sequence:
MALLDLALEGMAVFGFVLFLVLWLMHFMAIIYTRLHLNKKATDKQPYSKLPGVSLLKPLKGVDPNLINNLETFFELDYPKYEVLLCVQDHDDPAIDVCKKLLGKYPNVDARLFIGGKKVGINPKINNLMPGYEVAKYDLIWICDSGIRVIPDTLTDMVNQMTEKVGLVHGLPYVADRQGFAATLEQVYFGTSHPRYYISANVTGFKCVTGMSCLMRKDVLDQAGGLIAFAQYIAEDYFMAKAIADRGWRFAMSTQVAMQNSGSYSISQFQSRMIRWTKLRINMLPATIICEPISECFVASLIIGWAAHHVFRWDIMVFFMCHCLAWFIFDYIQLRGVQGGTLCFSKLDYAVAWFIRESMTIYIFLSALWDPTISWRTGRYRLRCGGTAEEILDV
  
Inhibitor
Name:
BDBM576427
Synonyms:
WO2022115301, Example 13
Type:
Small organic molecule
Emp. Form.:
C24H27N3O3
Mol. Mass.:
405.4895
SMILES:
CC1=NNC(O1)c1cccc(c1)-c1cccc2CN([C@H](C3CC3)C(C)(C)O)C(=O)c12 |r,t:1|
Structure:
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