Target
Ceramide glucosyltransferase
Ligand
BDBM576428
Substrate
n/a
Meas. Tech.
UDP-Glo Glucosylceramide Synthase Biochemical Assay
EC50
48±n/a nM
Citation
 J., BME., FMMarie, LHJ., MJJ., RAM., SKJ., SS MODIFIED ISOINDOLINONES AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS WIPO 0:0 (2022) [PubMed] 
Target
Name:
Ceramide glucosyltransferase
Synonyms:
CEGT_HUMAN | GCS | GLCT-1 | Glucosylceramide synthase | UDP-glucose ceramide glucosyltransferase | UDP-glucose:N-acylsphingosine D-glucosyltransferase | UGCG
Type:
PROTEIN
Mol. Mass.:
44859.25
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1435474
Residue:
394
Sequence:
MALLDLALEGMAVFGFVLFLVLWLMHFMAIIYTRLHLNKKATDKQPYSKLPGVSLLKPLKGVDPNLINNLETFFELDYPKYEVLLCVQDHDDPAIDVCKKLLGKYPNVDARLFIGGKKVGINPKINNLMPGYEVAKYDLIWICDSGIRVIPDTLTDMVNQMTEKVGLVHGLPYVADRQGFAATLEQVYFGTSHPRYYISANVTGFKCVTGMSCLMRKDVLDQAGGLIAFAQYIAEDYFMAKAIADRGWRFAMSTQVAMQNSGSYSISQFQSRMIRWTKLRINMLPATIICEPISECFVASLIIGWAAHHVFRWDIMVFFMCHCLAWFIFDYIQLRGVQGGTLCFSKLDYAVAWFIRESMTIYIFLSALWDPTISWRTGRYRLRCGGTAEEILDV
  
Inhibitor
Name:
BDBM576428
Synonyms:
WO2022115301, Example 14
Type:
Small organic molecule
Emp. Form.:
C23H24F3NO3
Mol. Mass.:
419.4368
SMILES:
CC(C)(O)[C@@H](C1CC1)N1Cc2cccc(c2C1=O)-c1cccc(OCC(F)(F)F)c1 |r|
Structure:
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