Target
Coagulation factor XIII A chain
Ligand
BDBM577483
Substrate
n/a
Meas. Tech.
Isopeptidase Assay for Estimating Inhibitor Potency
IC50
8.00±n/a nM
Citation
 Hils, MPasternack, RBüchold, C Inhibitors of blood coagulation factor XIII US Patent  US11472838 Publication Date 10/18/2022 
Target
Name:
Coagulation factor XIII A chain
Synonyms:
Coagulation factor XIIIa | F13A_RAT | F13a | F13a1 | Protein-glutamine gamma-glutamyltransferase A chain | Transglutaminase A chain
Type:
Protein
Mol. Mass.:
82646.68
Organism:
Rat
Description:
O08619
Residue:
732
Sequence:
MSDTPATTFGGRGAIPPNNSNAAGVDLPTEDLQGLVPRGVSLKDYLNVTAVHLFKERWDSNKIVHHTDKFDNNKLIVRRGQTFYIQIDFNRPYDPRKDLFRVEYVIGRYPQENKGTYIPVPVVTELQSGKWGAKVIMNEDRSVRLSVQSSPECIVGKFRMYVAVWTPYGILRTQRDPETDTYILFNPWCEEDAVYLDDEKEREEYVLNDIGGIFHGDFNDIKSRSWSYGQFEDGILDACLFVMDKAEMDLSGRGNPIKVSRVGSAMVNAKDDEGVLVGSWDNVYAYGIPPSAWTGSVDILLEYRSSETPVRYGQCWVLAGVFNTFLRCLGIPARVITNYSSAHDNDANLQMDIFLEEDGSVSFKLTKDSVWNYHCWNEAWMTRPDLPVGFGGWQAVDSTPQENSDGMYRCGPASVQAVKHGHVCFQFDAPFVLGEVNSDLVYITAKKDGTHVVENVDATHIGKLIVTKEIGGDGMQDITDTYKFQEGQEEERLALETALMYGAKKTLNTEGMVKSSSDVDMNFDVENAVLGKDFRVTITFQNNSSNLYTILAYLSGNITFYTGVSKKEFKTESFEVTLDPLSLEKKEVLIRAGEYMSYLLEQGLLHFFVTARINETRVVLAKQKAIVLTIPKVTIKVRGTAMVGSDMVVTVEFTNPLKETLKNVWLHLEGPGVMRPKRKMFREIRPNATVQWEEVCQPWVSGHRKLNASMTSDSLRHVYGELDLQIRRRPTV
  
Inhibitor
Name:
BDBM577483
Synonyms:
US11472838, Compound 5
Type:
Small organic molecule
Emp. Form.:
C42H59N7O11
Mol. Mass.:
837.9582
SMILES:
COC(=O)\C=C\CC[C@H](NC(=O)c1ccncc1C(O)=O)C(=O)N[C@H](C(=O)N1CC(=O)C[C@H]1C(=O)N[C@@H](C1CCCCC1)C(=O)N[C@@H](C1CCCCC1)C(N)=O)C(C)(C)C |r|
Structure:
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