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Target
Prostaglandin E2 receptor EP4 subtype
Ligand
BDBM578774
Substrate
n/a
Meas. Tech.
EP4 Antagonistic Activity Measurement
IC50
0.790±n/a nM
Citation
 Asada, M; Tani, K; Higuchi, S EP4 antagonist US Patent  US11479550 Publication Date 10/25/2022 
Target
Name:
Prostaglandin E2 receptor EP4 subtype
Synonyms:
Prostanoid EP4 receptor | PGE receptor EP4 subtype | PGE2 receptor EP4 subtype | PE2R4_HUMAN | PTGER4 | PTGER2 | Prostaglandin E2 receptor
Type:
Enzyme
Mol. Mass.:
53134.53
Organism:
Human
Description:
P35408
Residue:
488
Sequence:
MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQPSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSGQHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPGMGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSETLNLSEKCI
  
Inhibitor
Name:
BDBM578774
Synonyms:
US11479550, Example 13 | 4-[2-({2-[3-methyl-6-(methylcarbamoyl)-1H-indol-1-yl]propanoyl}amino)-4-phenoxyphenyl]butanoic acid
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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