Reaction Details Report a problem with these data
Target
Sal-like protein 4
Ligand
BDBM585367
Substrate
n/a
Meas. Tech.
TBD
IC50
2231±n/a nM
Citation
 Qi, J; Varca, A; Chai, L Small molecule inhibition of transcription factor SALL4 and uses thereof US Patent  US11530209 Publication Date 12/20/2022 
Target
Name:
Sal-like protein 4
Synonyms:
SALL4 | SALL4_HUMAN | ZNF797 | Zinc finger protein 797 | Zinc finger protein SALL4
Type:
Protein
Mol. Mass.:
112246.17
Organism:
Human
Description:
Q9UJQ4
Residue:
1053
Sequence:
MSRRKQAKPQHINSEEDQGEQQPQQQTPEFADAAPAAPAAGELGAPVNHPGNDEVASEDEATVKRLRREETHVCEKCCAEFFSISEFLEHKKNCTKNPPVLIMNDSEGPVPSEDFSGAVLSHQPTSPGSKDCHRENGGSSEDMKEKPDAESVVYLKTETALPPTPQDISYLAKGKVANTNVTLQALRGTKVAVNQRSADALPAPVPGANSIPWVLEQILCLQQQQLQQIQLTEQIRIQVNMWASHALHSSGAGADTLKTLGSHMSQQVSAAVALLSQKAGSQGLSLDALKQAKLPHANIPSATSSLSPGLAPFTLKPDGTRVLPNVMSRLPSALLPQAPGSVLFQSPFSTVALDTSKKGKGKPPNISAVDVKPKDEAALYKHKCKYCSKVFGTDSSLQIHLRSHTGERPFVCSVCGHRFTTKGNLKVHFHRHPQVKANPQLFAEFQDKVAAGNGIPYALSVPDPIDEPSLSLDSKPVLVTTSVGLPQNLSSGTNPKDLTGGSLPGDLQPGPSPESEGGPTLPGVGPNYNSPRAGGFQGSGTPEPGSETLKLQQLVENIDKATTDPNECLICHRVLSCQSSLKMHYRTHTGERPFQCKICGRAFSTKGNLKTHLGVHRTNTSIKTQHSCPICQKKFTNAVMLQQHIRMHMGGQIPNTPLPENPCDFTGSEPMTVGENGSTGAICHDDVIESIDVEEVSSQEAPSSSSKVPTPLPSIHSASPTLGFAMMASLDAPGKVGPAPFNLQRQGSRENGSVESDGLTNDSSSLMGDQEYQSRSPDILETTSFQALSPANSQAESIKSKSPDAGSKAESSENSRTEMEGRSSLPSTFIRAPPTYVKVEVPGTFVGPSTLSPGMTPLLAAQPRRQAKQHGCTRCGKNFSSASALQIHERTHTGEKPFVCNICGRAFTTKGNLKVHYMTHGANNNSARRGRKLAIENTMALLGTDGKRVSEIFPKEILAPSVNVDPVVWNQYTSMLNGGLAVKTNEISVIQSGGVPTLPVSLGATSVVNNATVSKMDGSQSGISADVEKPSATDGVPKHQFPHFLEENKIAVS
  
Inhibitor
Name:
BDBM585367
Synonyms:
US11530209, Compound A4
Type:
Small organic molecule
Emp. Form.:
C23H24N4O2
Mol. Mass.:
388.4623
SMILES:
Oc1ccc2ccccc2c1-c1nc2ccccn2c1NCCN1CCOCC1 |(-2.5,-4.98,;-3.27,-3.64,;-4.81,-3.64,;-5.58,-2.31,;-4.81,-.98,;-5.58,.36,;-4.81,1.69,;-3.27,1.69,;-2.5,.36,;-3.27,-.98,;-2.5,-2.31,;-.96,-2.31,;-.05,-3.56,;1.41,-3.08,;2.75,-3.85,;4.08,-3.08,;4.08,-1.54,;2.75,-.77,;1.41,-1.54,;-.05,-1.06,;-.53,.4,;.5,1.54,;2.01,1.22,;3.04,2.37,;4.55,2.05,;5.58,3.19,;5.1,4.66,;3.59,4.98,;2.56,3.83,)|
Structure:
Search PDB for entries with ligand similarity: