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Target
Sal-like protein 4
Ligand
BDBM585371
Substrate
n/a
Meas. Tech.
TBD
IC50
335±n/a nM
Citation
 Qi, J; Varca, A; Chai, L Small molecule inhibition of transcription factor SALL4 and uses thereof US Patent  US11530209 Publication Date 12/20/2022 
Target
Name:
Sal-like protein 4
Synonyms:
SALL4 | SALL4_HUMAN | ZNF797 | Zinc finger protein 797 | Zinc finger protein SALL4
Type:
Protein
Mol. Mass.:
112246.17
Organism:
Human
Description:
Q9UJQ4
Residue:
1053
Sequence:
MSRRKQAKPQHINSEEDQGEQQPQQQTPEFADAAPAAPAAGELGAPVNHPGNDEVASEDEATVKRLRREETHVCEKCCAEFFSISEFLEHKKNCTKNPPVLIMNDSEGPVPSEDFSGAVLSHQPTSPGSKDCHRENGGSSEDMKEKPDAESVVYLKTETALPPTPQDISYLAKGKVANTNVTLQALRGTKVAVNQRSADALPAPVPGANSIPWVLEQILCLQQQQLQQIQLTEQIRIQVNMWASHALHSSGAGADTLKTLGSHMSQQVSAAVALLSQKAGSQGLSLDALKQAKLPHANIPSATSSLSPGLAPFTLKPDGTRVLPNVMSRLPSALLPQAPGSVLFQSPFSTVALDTSKKGKGKPPNISAVDVKPKDEAALYKHKCKYCSKVFGTDSSLQIHLRSHTGERPFVCSVCGHRFTTKGNLKVHFHRHPQVKANPQLFAEFQDKVAAGNGIPYALSVPDPIDEPSLSLDSKPVLVTTSVGLPQNLSSGTNPKDLTGGSLPGDLQPGPSPESEGGPTLPGVGPNYNSPRAGGFQGSGTPEPGSETLKLQQLVENIDKATTDPNECLICHRVLSCQSSLKMHYRTHTGERPFQCKICGRAFSTKGNLKTHLGVHRTNTSIKTQHSCPICQKKFTNAVMLQQHIRMHMGGQIPNTPLPENPCDFTGSEPMTVGENGSTGAICHDDVIESIDVEEVSSQEAPSSSSKVPTPLPSIHSASPTLGFAMMASLDAPGKVGPAPFNLQRQGSRENGSVESDGLTNDSSSLMGDQEYQSRSPDILETTSFQALSPANSQAESIKSKSPDAGSKAESSENSRTEMEGRSSLPSTFIRAPPTYVKVEVPGTFVGPSTLSPGMTPLLAAQPRRQAKQHGCTRCGKNFSSASALQIHERTHTGEKPFVCNICGRAFTTKGNLKVHYMTHGANNNSARRGRKLAIENTMALLGTDGKRVSEIFPKEILAPSVNVDPVVWNQYTSMLNGGLAVKTNEISVIQSGGVPTLPVSLGATSVVNNATVSKMDGSQSGISADVEKPSATDGVPKHQFPHFLEENKIAVS
  
Inhibitor
Name:
BDBM585371
Synonyms:
US11530209, Compound E1
Type:
Small organic molecule
Emp. Form.:
C19H16N4O
Mol. Mass.:
316.3565
SMILES:
Oc1ccc2ccccc2c1-c1nc2cnccn2c1NC1CC1 |(-1.75,-4.01,;-2.52,-2.68,;-4.06,-2.68,;-4.83,-1.35,;-4.06,-.01,;-4.83,1.32,;-4.06,2.65,;-2.52,2.65,;-1.75,1.32,;-2.52,-.01,;-1.75,-1.35,;-.21,-1.35,;.7,-2.59,;2.16,-2.12,;3.49,-2.89,;4.83,-2.12,;4.83,-.58,;3.49,.19,;2.16,-.58,;.7,-.1,;.22,1.36,;1.25,2.51,;2.72,2.98,;1.57,4.01,)|
Structure:
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