Target
Isoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Ligand
BDBM589758
Substrate
n/a
Meas. Tech.
Cytokine Assays
IC50
0.640±n/a nM
Citation
 Strohbach, JWAkama, TBlakemore, DCJacobs, RTJones, PLimburg, DCOderinde, MSPerry, MAPlattner, JJTorella, RFZhou, YYeoh, TY Substituted 1,2-oxaborolan-2-ols as PDE4 inhibitors US Patent  US11559538 Publication Date 1/24/2023 
Target
Name:
Isoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2)
Synonyms:
DPDE4 | PDE4B | PDE4B2 | PDE4B_HUMAN | cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2) | phosphodiesterase 4B2
Type:
Enzyme
Mol. Mass.:
64320.36
Organism:
Homo sapiens (Human)
Description:
Q07343-2
Residue:
564
Sequence:
MKEHGGTFSSTGISGGSGDSAMDSLQPLQPNYMPVCLFAEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGETDIDIATEDKSPVDT
  
Inhibitor
Name:
BDBM589758
Synonyms:
US11559538, Example 189 | US11559538, Example 21 | US11559538, Example 53
Type:
Small organic molecule
Emp. Form.:
C18H22BNO4
Mol. Mass.:
327.183
SMILES:
CCOc1cc(ccc1OC)-c1cncc(C2COB(O)C2)c1C
Structure:
Search PDB for entries with ligand similarity: