Target
Isoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Ligand
BDBM589867
Substrate
n/a
Meas. Tech.
Cytokine Assays
IC50
0.690±n/a nM
Citation
 Strohbach, JWAkama, TBlakemore, DCJacobs, RTJones, PLimburg, DCOderinde, MSPerry, MAPlattner, JJTorella, RFZhou, YYeoh, TY Substituted 1,2-oxaborolan-2-ols as PDE4 inhibitors US Patent  US11559538 Publication Date 1/24/2023 
Target
Name:
Isoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2)
Synonyms:
DPDE4 | PDE4B | PDE4B2 | PDE4B_HUMAN | cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2) | phosphodiesterase 4B2
Type:
Enzyme
Mol. Mass.:
64320.36
Organism:
Homo sapiens (Human)
Description:
Q07343-2
Residue:
564
Sequence:
MKEHGGTFSSTGISGGSGDSAMDSLQPLQPNYMPVCLFAEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGETDIDIATEDKSPVDT
  
Inhibitor
Name:
BDBM589867
Synonyms:
US11559538, Example 121
Type:
Small organic molecule
Emp. Form.:
C17H20BNO4
Mol. Mass.:
313.156
SMILES:
CCOc1nc(ccc1OC)-c1cccc(c1)C1COB(O)C1
Structure:
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