Reaction Details Report a problem with these data
Target
Apoptosis regulator Bcl-2
Ligand
BDBM361577
Substrate
n/a
Meas. Tech.
Bcl-2 and Bcl-xL Inhibition Assay
IC50
2.00±n/a nM
Citation
 Wang, S; Chen, J N-(phenylsulfonyl)benzamides and related compounds as Bcl-2 inhibitors US Patent  US11718613 Publication Date 8/8/2023 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | Bcl-2 Protein | BCL2_HUMAN | BCL2
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Human
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM361577
Synonyms:
(S)-N-((4-(((1,4-dioxan-2-yl)methyl)amino)-3- nitrophenyl)sulfonyl)-2-((1H-pyrrolo[2,3-b]pyridin- 5-yl)oxy)-4-(4-((6-(4-chlorophenyl)spiro[3.5]non-6- en-7-yl)methyl)piperazin-1-yl)benzamide | US10221174, Compound 6 | US10829488, Compound 6 | US11718613, Compound 6
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
[O-][N+](=O)c1cc(ccc1NC[C@H]1COCCO1)S(=O)(=O)NC(=O)c1ccc(cc1Oc1cnc2[nH]ccc2c1)N1CCN(CC2=C(CC3(CCC3)CC2)c2ccc(Cl)cc2)CC1 |r,t:49|
Structure:
Search PDB for entries with ligand similarity: