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Target
Bcl-2-like protein 1
Ligand
BDBM361578
Substrate
n/a
Meas. Tech.
Bcl-2 and Bcl-xL Inhibition Assay
IC50
20.6±n/a nM
Citation
 Wang, S; Chen, J N-(phenylsulfonyl)benzamides and related compounds as Bcl-2 inhibitors US Patent  US11718613 Publication Date 8/8/2023 
Target
Name:
Bcl-2-like protein 1
Synonyms:
Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | BCL2-like 1 isoform 1 | Bcl-2-like protein 1 (Bcl-XL) | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD) | Bcl-X | B2CL1_HUMAN | BCL2L1 | BCL2L | BCLX | Bcl-xL/Bcl-2-binding component 3
Type:
Mitochondrion membrane; Single-pass membrane protein
Mol. Mass.:
26039.60
Organism:
Human
Description:
n/a
Residue:
233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
  
Inhibitor
Name:
BDBM361578
Synonyms:
2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(1-((6-(4- chlorophenyl)spiro[3.5]non-6-en-7-yl)methyl)- 1,2,3,6-tetrahydropyridin-4-yl)-N-((3-nitro-4- (((tetrahydro-2H-pyran-4- yl)methyl)amino)phenyl)sulfonyl)benzamide | US10221174, Compound 7 | US10829488, Compound 7 | US11718613, Compound 9
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
[O-][N+](=O)c1cc(ccc1NCC1CCOCC1)S(=O)(=O)NC(=O)c1ccc(cc1Oc1cnc2[nH]ccc2c1)C1=CCN(CC2=C(CC3(CCC3)CC2)c2ccc(Cl)cc2)CC1 |t:44,49|
Structure:
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