Reaction Details Report a problem with these data
Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM535242
Substrate
n/a
Meas. Tech.
USP7 Assay A (Ubitquin-Rhodamine110 Assay)
IC50
0.500±n/a nM
Citation
 FERRARI, N; SAINI, HK; AHN, JS BIOMARKERS FOR CANCER THERAPY USING MDM2 ANTAGONISTS US Patent  US20230338337 Publication Date 10/26/2023 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
MDM2_HUMAN | MDM2 | Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | p53-Binding Protein MDM2 | p53-binding protein | MDM2-MDMX
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Human
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM535242
Synonyms:
6-{[(1R)-1-(4-chlorophenyl)-7-fluoro- 1-{[2- (hydroxymethyl)cyclopentyl]oxy}-5-(2- hydroxypropan-2-yl)-3-oxo-2,3- dihydro-1H-isoindol-2- yl]methyl}pyridine-3-carbonitrile | US11236047, Example 74 | US11236047, Example 73 | US20230338337, Example 74
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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