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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM535445
Substrate
n/a
Meas. Tech.
USP7 Assay B (Ubitquin-Rhodamine110 Assay)
IC50
0.840±n/a nM
Citation
 FERRARI, N; SAINI, HK; AHN, JS BIOMARKERS FOR CANCER THERAPY USING MDM2 ANTAGONISTS US Patent  US20230338337 Publication Date 10/26/2023 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
MDM2_HUMAN | MDM2 | Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | p53-Binding Protein MDM2 | p53-binding protein | MDM2-MDMX
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Human
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM535445
Synonyms:
(3R)-6-[1-(1-acetylpiperidin-4-yl)-1- hydroxyethyl]-3-(4-chlorophenyl)-2- [(5-chloropyridin-2-yl)methyl]-4-fluoro- 3-(2-hydroxyethoxy)-2,3-dihydro-1H- isoindol-1-one | US11236047, Example 421 | US20230338337, Compound 421
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
CC(=O)N1CCC(CC1)C(C)(O)c1cc2C(=O)N(Cc3ccc(Cl)cn3)[C@](OCCO)(c2c(F)c1)c1ccc(Cl)cc1 |r|
Structure:
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