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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM535732
Substrate
n/a
Meas. Tech.
USP7 Assay B (Ubitquin-Rhodamine110 Assay)
IC50
1.10±n/a nM
Citation
 FERRARI, N; SAINI, HK; AHN, JS BIOMARKERS FOR CANCER THERAPY USING MDM2 ANTAGONISTS US Patent  US20230338337 Publication Date 10/26/2023 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
MDM2_HUMAN | MDM2 | Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | p53-Binding Protein MDM2 | p53-binding protein | MDM2-MDMX
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Human
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM535732
Synonyms:
6-{[(1R)-1-(4-chlorophenyl)-7-fluoro- 1-{[1- (hydroxymethyl)cyclopropyl]methoxy}- 3-oxo-5-(1,1,1-trifluoro-2- hydroxypropan-2-yl)-2,3-dihydro-1H- isoindol-2-yl]methyl}pyridine-3- carbonitrile | US11236047, Example 417 | US11236047, Example 416 | US20230338337, Compound 417
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
CC(O)(c1cc2C(=O)N(Cc3ccc(cn3)C#N)[C@](OCC3(CO)CC3)(c2c(F)c1)c1ccc(Cl)cc1)C(F)(F)F |r|
Structure:
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