Target
Ketohexokinase
Ligand
BDBM655985
Substrate
n/a
Meas. Tech.
Inhibitory Activity Against KHK In Vitro
EC50
134±n/a nM
Citation
 LI, YWANG, WCHEN, LZHANG, GZHANG, XHU, GWANG, YWANG, HTANG, PYU, YZHANG, CYAN, P KETOHEXOKINASE INHIBITOR AND USE THEREOF US Patent  US20240067633 Publication Date 2/29/2024 
Target
Name:
Ketohexokinase
Synonyms:
Hepatic fructokinase
Type:
Protein
Mol. Mass.:
32748.45
Organism:
Mouse
Description:
P97328
Residue:
298
Sequence:
MEEKQILCVGLVVLDIINVVDKYPEEDTDRRCLSQRWQRGGNASNSCTVLSLLGARCAFMGSLAPGHVADFLVADFRQRGVDVSQVTWQSQGDTPCSCCIVNNSNGSRTIILYDTNLPDVSAKDFEKVDLTRFKWIHIEGRNASEQVKMLQRIEEHNAKQPLPQKVRVSVEIEKPREELFQLFSYGEVVFVSKDVAKHLGFQPAVEALRGLYSRVKKGATLVCAWAEEGADALGPDGQLLHSDAFPPPRVVDTLGAGDTFNASVIFSLSKGNSMQEALRFGCQVAGKKCGLQGFDGIV
  
Inhibitor
Name:
BDBM655985
Synonyms:
US20240067633, Isomer 2 of compound 3
Type:
Small organic molecule
Emp. Form.:
C20H26F2N4O2
Mol. Mass.:
392.4428
SMILES:
C[C@H]1CCN1c1nc(N2C[C@@H]3C[C@H](C2)[C@H]3CC(O)=O)c2CCCC(F)(F)c2n1 |r|
Structure:
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