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Target
Pantetheinase
Ligand
BDBM657905
Substrate
n/a
Meas. Tech.
Enzyme Activity Inhibition Assay
IC50
2.40±n/a nM
Citation
 Yao, Y; Ye, G; Luan, L; Chen, Y; Wang, C PYRIMIDINE CARBOXAMIDE COMPOUND AND APPLICATION THEREOF US Patent  US20240083873 Publication Date 3/14/2024 
Target
Name:
Pantetheinase
Synonyms:
VNN1_HUMAN | VNN1 | Pantetheine hydrolase | Tiff66 | Vanin-1 | Vascular non-inflammatory molecule 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57002.46
Organism:
Human
Description:
O95497
Residue:
513
Sequence:
MTTQLPAYVAILLFYVSRASCQDTFTAAVYEHAAILPNATLTPVSREEALALMNRNLDILEGAITSAADQGAHIIVTPEDAIYGWNFNRDSLYPYLEDIPDPEVNWIPCNNRNRFGQTPVQERLSCLAKNNSIYVVANIGDKKPCDTSDPQCPPDGRYQYNTDVVFDSQGKLVARYHKQNLFMGENQFNVPKEPEIVTFNTTFGSFGIFTCFDILFHDPAVTLVKDFHVDTIVFPTAWMNVLPHLSAVEFHSAWAMGMRVNFLASNIHYPSKKMTGSGIYAPNSSRAFHYDMKTEEGKLLLSQLDSHPSHSAVVNWTSYASSIEALSSGNKEFKGTVFFDEFTFVKLTGVAGNYTVCQKDLCCHLSYKMSENIPNEVYALGAFDGLHTVEGRYYLQICTLLKCKTTNLNTCGDSAETASTRFEMFSLSGTFGTQYVFPEVLLSENQLAPGEFQVSTDGRLFSLKPTSGPVLTVTLFGRLYEKDWASNASSGLTAQARIIMLIVIAPIVCSLSW
  
Inhibitor
Name:
BDBM657905
Synonyms:
US20240083873, Compound 2-1
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
O=C(N1CCC2(C1)CCOCC2)c1cnc(N[C@@H]2CCc3ncccc23)nc1 |r|
Structure:
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