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Target
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1
Ligand
BDBM601952
Substrate
n/a
Meas. Tech.
CDK Inhibition In Vitro Assay
IC50
3.00±n/a nM
Citation
 Strum, JC CYCLIN-DEPENDENT KINASE INHIBITING COMPOUNDS FOR THE TREATMENT OF MEDICAL DISORDERS US Patent  US20240150369 Publication Date 5/9/2024 
Target
Name:
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1
Synonyms:
CDK4/CycD | CDK4/CycD1 | CDK4/Cyclin D1 | CDK4/D1 | Cyclin-dependent kinase 4 | Cyclin-Dependent Kinase 4 (CDK4) | Cyclin-dependent kinase 4/cyclin D1 | Cyclin-dependent kinase 4/G1/S-specific cyclin D1
Type:
Protein Complex
Mol. Mass.:
n/a
Description:
CDK4/D1 complexes were purified from insect cells co-infected with baculovirus vectors containing each of the components.
Components:
This complex has 2 components.
Component 1
Name:
Cyclin-dependent kinase 4
Synonyms:
Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3 | CDK4_HUMAN | CDK4
Type:
Enzyme Subunit
Mol. Mass.:
33731.96
Organism:
Human
Description:
P11802
Residue:
303
Sequence:
MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE
  
Component 2
Name:
G1/S-specific cyclin-D1
Synonyms:
B-cell lymphoma 1 protein | BCL-1 oncogene | BCL-1 | PRAD1 oncogene | CCND1_HUMAN | CCND1 | BCL1 | PRAD1
Type:
Enzyme Subunit
Mol. Mass.:
33717.70
Organism:
Human
Description:
n/a
Residue:
295
Sequence:
MEHQLLCCEVETIRRAYPDANLLNDRVLRAMLKAEETCAPSVSYFKCVQKEVLPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPVKKSRLQLLGATCMFVASKMKETIPLTAEKLCIYTDNSIRPEELLQMELLLVNKLKWNLAAMTPHDFIEHFLSKMPEAEENKQIIRKHAQTFVALCATDVKFISNPPSMVAAGSVVAAVQGLNLRSPNNFLSYYRLTRFLSRVIKCDPDCLRACQEQIEALLESSLRQAQQNMDPKAAEEEEEEEEEVDLACTPTDVRDVDI
  
Inhibitor
Name:
BDBM601952
Synonyms:
US11643416, Compound 54 | 2'-((4-(4-methylpiperazine-1- carbonyl)phenyl)amino)-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5- a:2,3-d']dipyrimidin]-7'(8'H)-one | US20240150369, Compound 54 | US20250270226, Compound 54
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
CN1CCN(CC1)C(=O)c1ccc(Nc2ncc3cc4NC(=O)CC5(CCCCC5)n4c3n2)cc1
Structure:
Search PDB for entries with ligand similarity: