Reaction Details Report a problem with these data
Target
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma
Ligand
BDBM691400
Substrate
n/a
Meas. Tech.
Inhibition Activity
Kd
42.0±n/a nM
Citation
 Gray, NS; Teng, M; Wang, E; Jiang, J; Zhang, T; Cantley, LC; Fischer, ES; Donovan, KA INHIBITORS AND DEGRADERS OF PIP4K PROTEIN US Patent  US20240277852 Publication Date 8/22/2024 
Target
Name:
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma
Synonyms:
Phosphatidylinositol-5-phosphate 4-kinase type II gamma | PIP4KII-gamma | PI(5)P 4-kinase type II gamma | PI42C_HUMAN | PIP4K2C | PIP5K2C | Phosphatidylinositol-5-phosphate 4-kinase type-2 gamma
Type:
PROTEIN
Mol. Mass.:
47302.35
Organism:
Human
Description:
ChEMBL_774614
Residue:
421
Sequence:
MASSSVPPATVSAATAGPGPGFGFASKTKKKHFVQQKVKVFRAADPLVGVFLWGVAHSINELSQVPPPVMLLPDDFKASSKIKVNNHLFHRENLPSHFKFKEYCPQVFRNLRDRFGIDDQDYLVSLTRNPPSESEGSDGRFLISYDRTLVIKEVSSEDIADMHSNLSNYHQYIVKCHGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDFLNKNQKVYIGEEEKKIFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYIHSHRPLGPGEFESFIDVYAIRSAEGAPQKEVYFMGLIDILTQYDAKKKAAHAAKTVKHGAGAEISTVHPEQYAKRFLDFITNIFA
  
Inhibitor
Name:
BDBM691400
Synonyms:
US20240277852, Compound 57
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](NC(=O)CCCCCC(=O)N1CCC2(CCN(C2=O)c2cncc(Nc3ncc(Cl)c(n3)-c3cccc(c3)-c3ccccc3)c2)CC1)C(C)(C)C)c1ccc(cc1)-c1scnc1C |r|
Structure:
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