Reaction Details
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Target
Caspase-3
Ligand
BDBM10323
Substrate
Caspase Fluorogenic Substrate
Meas. Tech.
Caspase Inhibition Assay
Ki
1.2±n/a nM
IC50
2.5±n/a nM
Citation

More Info.:
Target
Name:
Caspase-3
Synonyms:
CPP-32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | Apopain | CASP-3 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein | CASP3_HUMAN | CASP3 | CPP32
Type:
Hydrolase; heterotetramer of two heterodimers
Mol. Mass.:
31607.55
Organism:
Human
Description:
n/a
Residue:
277
Sequence:
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
Inhibitor
Name:
BDBM10323
Synonyms:
JMC522188 Compound 2 | IST-3 | CHEMBL439753 | 1-benzyl-5-{[(2S)-2-(phenoxymethyl)pyrrolidine-1-]sulfonyl}-2,3-dihydro-1H-indole-2,3-dione | Pyrrolidine Isatin Analogue 2 | (S)-1-Benzyl-5-{1-[2-(phenoxymethyl)pyrrolidinyl]sulfonyl}isatin | Isatin Sulfonamide 34
Type:
Small organic molecule
Emp. Form.:
C26H24N2O5S
Mol. Mass.:
476.55
SMILES:
O=C1C(=O)N(Cc2ccccc2)c2ccc(S(=O)(=O)N3CCC[C@H]3COc3ccccc3)cc21
Substrate
Name:
Caspase Fluorogenic Substrate
Synonyms:
Caspase Fluorogenic Substrate | Ac-DEVD-AMC
Type:
Peptide
Mol. Mass.:
1461.77
Organism:
n/a
Description:
AMC=7-Amino-4-methylcoumarin
Residue:
16
Sequence:
ACASPGLVALASPAMC