Reaction Details Report a problem with these data
Target
Isocitrate dehydrogenase [NADP] cytoplasmic [R132H,S280F]
Ligand
BDBM719114
Substrate
n/a
Meas. Tech.
Assay for mIDH1 R132H/S280F
IC50
295±n/a nM
Citation
 ALVAREZ, FG; MANDAL, PK; HORTON, MC; SOTH, MJ; LE, K; JONES, P; MCAFOOS, TJ; SRIVASTAVA, P INHIBITORS OF MUTANT IDH1 AND IDH2 US Patent  US20250049809 Publication Date 2/13/2025 
Target
Name:
Isocitrate dehydrogenase [NADP] cytoplasmic [R132H,S280F]
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
46701.83
Organism:
Human
Description:
O75874[R132H,S280F]
Residue:
414
Sequence:
MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDFVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL
  
Inhibitor
Name:
BDBM719114
Synonyms:
US20250049809, Example 4
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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