Target
Orexin/Hypocretin receptor type 1
Ligand
BDBM143781
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
175±n/a nM
Citation
 Gelin, CFLebold, TPShireman, BTZiff, JM Substituted 2-azabicycles and their use as orexin receptor modulators US Patent  US9611277 Publication Date 4/4/2017 
Target
Name:
Orexin/Hypocretin receptor type 1
Synonyms:
HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r
Type:
Protein
Mol. Mass.:
47554.50
Organism:
Homo sapiens (Human)
Description:
O43613
Residue:
425
Sequence:
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP
  
Inhibitor
Name:
BDBM143781
Synonyms:
US10183953, Example 42 | US8969352, 42 | US9611277, Example 42 | US9845333, 42
Type:
Small organic molecule
Emp. Form.:
C21H18F3N3O2
Mol. Mass.:
401.3817
SMILES:
FC(F)(F)c1ccc(OC2CC3CC2N(C3)C(=O)c2cccc3cc[nH]c23)nc1 |TLB:16:14:9.10:12,THB:8:9:14.15:12|
Structure:
Search PDB for entries with ligand similarity: