Reaction Details Report a problem with these data
Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM317216
Substrate
n/a
Meas. Tech.
Enzymatic IDO Assay
IC50
550±n/a nM
Citation
 Kumar, S; Waldo, J; Jaipuri, F; Mautino, M Tricyclic compounds as inhibitors of immunosuppression mediated by tryptophan metabolization US Patent  US9617272 Publication Date 4/11/2017 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
IDO-1 | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine-pyrrole 2,3-dioxygenase | I23O1_HUMAN | IDO1 | IDO | INDO | Indoleamine 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Human
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM317216
Synonyms:
US9617272, Compound 27 | US9981973, Compound 27
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
O=C(CC1c2cncn2-c2ccccc12)C1CCCCC1
Structure:
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