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Target
Isocitrate dehydrogenase [NADP] cytoplasmic [1-390,401-414,R132C]
Ligand
BDBM317537
Substrate
n/a
IC50
5500±n/a nM
Citation
 Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W Fused-bicyclic aryl quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors US Patent  US9624175 Publication Date 4/18/2017 
Target
Name:
Isocitrate dehydrogenase [NADP] cytoplasmic [1-390,401-414,R132C]
Synonyms:
Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1)(R132C) | IDHC_HUMAN | IDH1 | PICD
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45318.79
Organism:
Human
Description:
O75874[1-390,401-414,R132C]
Residue:
404
Sequence:
MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDLGENLKIKLAQAKL
  
Inhibitor
Name:
BDBM317537
Synonyms:
US9624175, Compound I-52 | 6-chloro-7-methoxy-3-[(1R)-1-({1-methyl-2-oxo-1H,2H,4H-pyrimido[4,5-d][1,3]oxazin-7-yl}amino)ethyl]-1,2-dihydroquinolin-2-one
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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