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Target
Carbonic anhydrase 2
Ligand
BDBM11408
Substrate
BDBM11402
Meas. Tech.
In vitro binding of inhibitor to hCA-II
Ki
0.1±n/a nM
Citation
 Chen, HH; Gross, S; Liao, J; McLaughlin, M; Dean, T; Sly, WS; May, JA 2H-Thieno[3,2-e]- and [2,3-e]-1,2-thiazine-6-sulfonamide 1,1-dioxides as ocular hypotensive agents: synthesis, carbonic anhydrase inhibition and evaluation in the rabbit. Bioorg Med Chem 8:957-75 (2000) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM11408
Synonyms:
1,1-dioxo-3-[(prop-2-yn-1-ylamino)methyl]-2-propyl-2H-1,7,2-thieno[3,2-e][1,2]thiazine-6-sulfonamide | 2-Propyl-3-[(2-propynylamino)methyl]-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide | 2H-Thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide 15 | Compound 17c8
Type:
Small organic molecule
Emp. Form.:
C13H17N3O4S3
Mol. Mass.:
375.487
SMILES:
CCCN1C(CNCC#C)=Cc2cc(sc2S1(=O)=O)S(N)(=O)=O |c:9|
Structure:
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Substrate
Name:
BDBM11402
Synonyms:
5-(dimethylamino)naphthalene-1-sulfonamide | dansylamide
Type:
Small organic molecule
Emp. Form.:
C12H14N2O2S
Mol. Mass.:
250.317
SMILES:
CN(C)c1cccc2c(cccc12)S(N)(=O)=O
Structure:
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