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Target
Orexin/Hypocretin receptor type 1
Ligand
BDBM164112
Substrate
n/a
Meas. Tech.
Rat and Human Orexin 1 Receptor Radioligand Binding Assay
Ki
41.0±n/a nM
Citation
 Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Substituted 7-azabicycles and their use as orexin receptor modulators US Patent  US9637496 Publication Date 5/2/2017 
Target
Name:
Orexin/Hypocretin receptor type 1
Synonyms:
HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r
Type:
Protein
Mol. Mass.:
47554.50
Organism:
Homo sapiens (Human)
Description:
O43613
Residue:
425
Sequence:
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP
  
Inhibitor
Name:
BDBM164112
Synonyms:
US9062078, 242 | US9475819, 242 | US9637496, 242 | US9695183, 242
Type:
Small organic molecule
Emp. Form.:
C21H20F3N7O2
Mol. Mass.:
459.4244
SMILES:
COc1cccc(c1C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F)-n1nccn1 |TLB:17:15:13.12:10|
Structure:
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