Reaction Details Report a problem with these data
Target
Coagulation factor X
Ligand
BDBM14058
Substrate
BDBM12593
Meas. Tech.
Enzyme Assay and Determination of the Inhibition Constants.
pH
7.5000±n/a
Temperature
295.1500±n/a K
Ki
22±n/a nM
Citation
 Maignan, S; Guilloteau, JP; Pouzieux, S; Choi-Sledeski, YM; Becker, MR; Klein, SI; Ewing, WR; Pauls, HW; Spada, AP; Mikol, V Crystal structures of human factor Xa complexed with potent inhibitors. J Med Chem 43:3226-32 (2000) [PubMed]  Article 
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor | FA10_HUMAN | F10
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Human
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM14058
Synonyms:
N-[(3S)-1-[(1-aminoisoquinolin-7-yl)methyl]-2-oxopyrrolidin-3-yl]thieno[3,2-b]pyridine-2-sulfonamide | N-[(3S)-1-[(1-aminoisoquinolin-7-yl)methyl]-2-oxo-pyrrolidin-3-yl]-7-thia-2-azabicyclo[4.3.0]nona-2,4,8,10-tetraene-8-sulfonamide | CHEMBL316053 | RPR208815
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM12593
Synonyms:
Methoxycarbonyl-D-cyclohexylglycyl-glycyl-arginine-para-nitroanilide acetate | MeO-CO-D-CHG-Gly-Arg-pNA.AcOH | acetic acid; methyl N-[(R)-[({[(1S)-4-carbamimidamido-1-[(4-nitrophenyl)carbamoyl]butyl]carbamoyl}methyl)carbamoyl](cyclohexyl)methyl]carbamate | Chromogenic Substrate Spectrozyme FXa
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: