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Target
Mitogen-activated protein kinase 10
Ligand
BDBM15618
Substrate
EGF receptor peptide
Meas. Tech.
Enzyme Inhibition Assay
Ki
2700±n/a nM
Citation
 Aronov, AM; Baker, C; Bemis, GW; Cao, J; Chen, G; Ford, PJ; Germann, UA; Green, J; Hale, MR; Jacobs, M; Janetka, JW; Maltais, F; Martinez-Botella, G; Namchuk, MN; Straub, J; Tang, Q; Xie, X Flipped out: structure-guided design of selective pyrazolylpyrrole ERK inhibitors. J Med Chem 50:1280-7 (2007) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 10
Synonyms:
JNK3 | JNK3A | MAP kinase p49 3F12 | MAPK10 | MK10_HUMAN | Mitogen-Activated Protein Kinase 10 (JNK3) | Mitogen-activated protein kinase 10 (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12) | Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1 | PRKM10 | SAPK1B | Stress-activated protein kinase JNK3 | c-Jun N-terminal kinase 3 (JNK3)
Type:
Enzyme
Mol. Mass.:
52586.89
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
464
Sequence:
MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR
  
Inhibitor
Name:
BDBM15618
Synonyms:
4-(4-(3-Chlorophenyl)-1H-pyrazol-3-yl)-N-((tetrahydrofuran-2-yl)methyl)-1H-pyrrole-2-carboxamide | 4-[4-(3-chlorophenyl)-1H-pyrazol-3-yl]-N-(oxolan-2-ylmethyl)-1H-pyrrole-2-carboxamide | Pyrrole Carboxamide Analog 5d
Type:
Small organic molecule
Emp. Form.:
C19H19ClN4O2
Mol. Mass.:
370.833
SMILES:
Clc1cccc(c1)-c1c[nH]nc1-c1c[nH]c(c1)C(=O)NCC1CCCO1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
EGF receptor peptide
Synonyms:
Epidermal Growth Factor Receptor Peptide (EGFRP)
Type:
Peptide
Mol. Mass.:
2318.63
Organism:
n/a
Description:
n/a
Residue:
21
Sequence:
KRELVEPLTPSGEAPNQALLR