Target
Proteinase-activated receptor 4
Ligand
BDBM176228
Substrate
n/a
Meas. Tech.
PAR4 FLIPR assay
Temperature
298.15±n/a K
EC50
39.0±n/a nM
Comments
extracted
Citation
 Banville, JRemillard, RRuediger, EHDeon, DHGagnon, MDube, LGuy, JPriestley, ESPosy, SLMaxwell, BDWong, PCLawrence, RMMiller, MM Imidazothiadiazole and imidazopyrazine derivatives as protease activated receptor 4 (PAR4) inhibitors for treating platelet aggregation US Patent  US10047103 Publication Date 8/14/2018 
Target
Name:
Proteinase-activated receptor 4
Synonyms:
Coagulation factor II receptor-like 3 | F2RL3 | PAR-4 | PAR4 | PAR4_HUMAN | Proteinase-activated receptor 4 | Proteinase-activated receptor 4 (PAR4) | Thrombin receptor-like 3
Type:
Protein
Mol. Mass.:
41145.16
Organism:
Homo sapiens (Human)
Description:
Q96RI0
Residue:
385
Sequence:
MWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDTLELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAAADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVHPLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASHWQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSNLLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSPGDTVASKASAEGGSRGMGTHSSLLQ
  
Inhibitor
Name:
BDBM176228
Synonyms:
US10047103, 261 | US9688695, 261
Type:
Small organic molecule
Emp. Form.:
C28H22N6O3S
Mol. Mass.:
522.578
SMILES:
COc1cc(OCc2csc(Nc3ccc4[nH]ccc4c3)n2)c2cc(oc2c1)-c1cn2nc(C)ccc2n1
Structure:
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