Reaction Details Report a problem with these data
Target
Methionine aminopeptidase 2
Ligand
BDBM17405
Substrate
BDBM17353
Meas. Tech.
Enzyme Inhibition Assay
Ki
0.9±n/a nM
Citation
 Marino, JP; Fisher, PW; Hofmann, GA; Kirkpatrick, RB; Janson, CA; Johnson, RK; Ma, C; Mattern, M; Meek, TD; Ryan, MD; Schulz, C; Smith, WW; Tew, DG; Tomazek, TA; Veber, DF; Xiong, WC; Yamamoto, Y; Yamashita, K; Yang, G; Thompson, SK Highly potent inhibitors of methionine aminopeptidase-2 based on a 1,2,4-triazole pharmacophore. J Med Chem 50:3777-85 (2007) [PubMed]  Article 
Target
Name:
Methionine aminopeptidase 2
Synonyms:
Initiation factor 2-associated 67 kDa glycoprotein | MAP 2 | MAP2_HUMAN | METAP2 | MNPEP | MetAP 2 | Methionine aminopeptidase 2 (MetAP2) | Methionine aminopeptidases (HsMetAP2) | P67EIF2 | Peptidase M 2 | p67
Type:
Enzyme
Mol. Mass.:
52884.45
Organism:
Homo sapiens (Human)
Description:
P50579
Residue:
478
Sequence:
MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKESGASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY
  
Inhibitor
Name:
BDBM17405
Synonyms:
1,2,4-Triazole Compound, 63 | N-(3,4-dimethoxyphenyl)-5-[(3-methylbut-2-en-1-yl)sulfanyl]-4H-1,2,4-triazol-3-amine
Type:
Small organic molecule
Emp. Form.:
C15H20N4O2S
Mol. Mass.:
320.41
SMILES:
COc1ccc(Nc2nnc(SCC=C(C)C)[nH]2)cc1OC |(-9.75,8.7,;-8.21,8.7,;-7.44,7.37,;-8.21,6.03,;-7.44,4.7,;-5.9,4.7,;-4.75,3.67,;-3.29,4.15,;-2.81,5.61,;-1.27,5.61,;-.8,4.15,;.67,3.67,;1.81,4.7,;3.28,4.22,;4.42,5.25,;5.89,4.78,;4.1,6.76,;-2.04,3.24,;-5.13,6.03,;-5.9,7.37,;-5.13,8.7,;-5.9,10.03,)|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM17353
Synonyms:
(2S)-2-amino-N-(4-methyl-2-oxo-2H-chromen-7-yl)-4-(methylsulfanyl)butanamide | L-methionine-7-amido-4-methylcoumarin | Met-AMC
Type:
Small organic molecule
Emp. Form.:
C15H18N2O3S
Mol. Mass.:
306.38
SMILES:
CSCC[C@H](N)C(=O)Nc1ccc2c(C)cc(=O)oc2c1 |r|
Structure:
Search PDB for entries with ligand similarity: