Target
Methionine aminopeptidase 2
Ligand
BDBM17411
Substrate
BDBM17353
Meas. Tech.
Enzyme Inhibition Assay
Ki
0.41±n/a nM
Citation
 Marino, JPFisher, PWHofmann, GAKirkpatrick, RBJanson, CAJohnson, RKMa, CMattern, MMeek, TDRyan, MDSchulz, CSmith, WWTew, DGTomazek, TAVeber, DFXiong, WCYamamoto, YYamashita, KYang, GThompson, SK Highly potent inhibitors of methionine aminopeptidase-2 based on a 1,2,4-triazole pharmacophore. J Med Chem 50:3777-85 (2007) [PubMed]  Article 
Target
Name:
Methionine aminopeptidase 2
Synonyms:
Initiation factor 2-associated 67 kDa glycoprotein | MAP 2 | MAP2_HUMAN | METAP2 | MNPEP | MetAP 2 | Methionine aminopeptidase 2 (MetAP2) | Methionine aminopeptidases (HsMetAP2) | P67EIF2 | Peptidase M 2 | p67
Type:
Enzyme
Mol. Mass.:
52884.45
Organism:
Homo sapiens (Human)
Description:
P50579
Residue:
478
Sequence:
MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKESGASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY
  
Inhibitor
Name:
BDBM17411
Synonyms:
1,2,4-Triazole Compound, 69 | methyl 4-[(5-{[(2-fluorophenyl)methyl]sulfanyl}-4H-1,2,4-triazol-3-yl)amino]benzoate
Type:
Small organic molecule
Emp. Form.:
C17H15FN4O2S
Mol. Mass.:
358.39
SMILES:
COC(=O)c1ccc(Nc2nnc(SCc3ccccc3F)[nH]2)cc1
Structure:
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Substrate
Name:
BDBM17353
Synonyms:
(2S)-2-amino-N-(4-methyl-2-oxo-2H-chromen-7-yl)-4-(methylsulfanyl)butanamide | L-methionine-7-amido-4-methylcoumarin | Met-AMC
Type:
Small organic molecule
Emp. Form.:
C15H18N2O3S
Mol. Mass.:
306.38
SMILES:
CSCC[C@H](N)C(=O)Nc1ccc2c(C)cc(=O)oc2c1 |r|
Structure:
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