Target
Cathepsin S
Ligand
BDBM19500
Substrate
BDBM19490
Meas. Tech.
Enzyme Inhibition Assay
pH
6.5±n/a
Temperature
295.15±n/a K
IC50
0.4±n/a nM
Citation
 Gauthier, JYBlack, WCCourchesne, ICromlish, WDesmarais, SHoule, RLamontagne, SLi, CSMassé, FMcKay, DJOuellet, MRobichaud, JTruchon, JFTruong, VLWang, QPercival, MD The identification of potent, selective, and bioavailable cathepsin S inhibitors. Bioorg Med Chem Lett 17:4929-33 (2007) [PubMed]  Article 
Target
Name:
Cathepsin S
Synonyms:
CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein
Type:
Protein
Mol. Mass.:
37507.38
Organism:
Homo sapiens (Human)
Description:
P25774
Residue:
331
Sequence:
MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVMLHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI
  
Inhibitor
Name:
BDBM19500
Synonyms:
(2R)-N-(1-cyanocyclopropyl)-3-[(2-methylpropane)sulfonyl]-2-{[(1S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethyl]amino}propanamide | trifluoroethylamine inhibitor, 10
Type:
Small organic molecule
Emp. Form.:
C19H23F4N3O3S
Mol. Mass.:
449.463
SMILES:
CC(C)CS(=O)(=O)C[C@H](N[C@@H](c1ccc(F)cc1)C(F)(F)F)C(=O)NC1(CC1)C#N |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM19490
Synonyms:
Cbz-Val-Val-Arg-AMC | Fluorogenic substrate | Z-Val-Val-Arg-AMC
Type:
n/a
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
n/a
Structure: