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Target
Prostaglandin D2 receptor 2
Ligand
BDBM21605
Substrate
BDBM21544
Meas. Tech.
Radioligand Binding Assay
Ki
23±n/a nM
EC50
107±n/a nM
Citation
 Crosignani, S; Page, P; Missotten, M; Colovray, V; Cleva, C; Arrighi, JF; Atherall, J; Macritchie, J; Martin, T; Humbert, Y; Gaudet, M; Pupowicz, D; Maio, M; Pittet, PA; Golzio, L; Giachetti, C; Rocha, C; Bernardinelli, G; Filinchuk, Y; Scheer, A; Schwarz, MK; Chollet, A Discovery of a New Class of Potent, Selective, and Orally Bioavailable CRTH2 (DP2) Receptor Antagonists for the Treatment of Allergic Inflammatory Diseases. J Med Chem 51:2227-2243 (2008) [PubMed]  Article 
Target
Name:
Prostaglandin D2 receptor 2
Synonyms:
CD_antigen=CD294 | CRTH2 | Chemoattractant Receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) | Chemoattractant receptor-homologous molecule expressed on Th2 cells | Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) | DL1R | G protein-coupled receptor 44 | G-protein coupled receptor 44 | GPR44 | PD2R2_HUMAN | PTGDR2 | Prostaglandin D2 | Prostaglandin D2 receptor 2 | Prostaglandin D2 receptor 2 (PGD2)
Type:
Enzyme
Mol. Mass.:
43295.45
Organism:
Homo sapiens (Human)
Description:
Q9Y5Y4
Residue:
395
Sequence:
MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCRMRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRIMCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRRPGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVANPVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRPEEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS
  
Inhibitor
Name:
BDBM21605
Synonyms:
2-[(3R)-5-chloro-1'-[(3-chlorophenyl)methyl]-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-2,2',5'-trione]acetic acid | Spiro-indolinone analogue, (R)-60
Type:
Small organic molecule
Emp. Form.:
C20H14Cl2N2O5
Mol. Mass.:
433.242
SMILES:
OC(=O)CN1C(=O)[C@@]2(CC(=O)N(Cc3cccc(Cl)c3)C2=O)c2cc(Cl)ccc12 |r|
Structure:
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Substrate
Name:
BDBM21544
Synonyms:
(5Z)-7-[(1R,2R,5S)-5-hydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-3-oxocyclopentyl]hept-5-enoic acid | 11-Dehydroprostaglandin F2 alpha | Prostaglandin D2 | [3H]PGD2
Type:
radiolabeled ligand
Emp. Form.:
C20H32O5
Mol. Mass.:
352.4651
SMILES:
CCCCC[C@H](O)\C=C\[C@@H]1[C@@H](C\C=C/CCCC(O)=O)[C@@H](O)CC1=O |r|
Structure:
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