Reaction Details Report a problem with these data
Target
Adenosine deaminase
Ligand
BDBM21957
Substrate
BDBM14487
Meas. Tech.
ADA Inhibition Assay
pH
7.0000±n/a
Temperature
298.1500±n/a K
Ki
26540±390 nM
Citation
 Ujjinamatada, RK; Phatak, P; Burger, AM; Hosmane, RS Inhibition of adenosine deaminase by analogues of adenosine and inosine, incorporating a common heterocyclic base, 4(7)-amino-6(5)H-imidazo[4,5-d]pyridazin-7(4)one. J Med Chem 51:694-8 (2008) [PubMed]  Article 
Target
Name:
Adenosine deaminase
Synonyms:
Adenosine aminohydrolase | ADA_BOVIN | ADA
Type:
Enzyme
Mol. Mass.:
40910.44
Organism:
Bovine
Description:
n/a
Residue:
363
Sequence:
MAQTPAFNKPKVELHVHLDGAIKPETILYYGRKRGIALPADTPEELQNIIGMDKPLSLPEFLAKFDYYMPAIAGCREAVKRIAYEFVEMKAKDGVVYVEVRYSPHLLANSKVEPIPWNQAEGDLTPDEVVSLVNQGLQEGERDFGVKVRSILCCMRHQPSWSSEVVELCKKYREQTVVAIDLAGDETIEGSSLFPGHVKAYAEAVKSGVHRTVHAGEVGSANVVKEAVDTLKTERLGHGYHTLEDATLYNRLRQENMHFEVCPWSSYLTGAWKPDTEHPVVRFKNDQVNYSLNTDDPLIFKSTLDTDYQMTKNEMGFTEEEFKRLNINAAKSSFLPEDEKKELLDLLYKAYGMPSPASAEQCL
  
Inhibitor
Name:
BDBM21957
Synonyms:
N'-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(hydrazinecarbonyl)-1H-imidazole-5-carboximidamide | 4-(hydrazinocarbonyl)-1-beta-D-ribofuranosyl-1H-imidazole-5-carbohydrazonamide | Carbohydrazonamide derivative, 11
Type:
n/a
Emp. Form.:
C10H17N7O5
Mol. Mass.:
315.13
SMILES:
NNC(=N)c1c(ncn1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O)C(=O)NN |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM14487
Synonyms:
[U-14C]adenosine | CHEMBL477 | cid_60961 | (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol | N6-Methylado | cid_191 | Adenine-beta-D-arabinofuranoside | Adenosine
Type:
Nucleoside or nucleotide
Emp. Form.:
C10H13N5O4
Mol. Mass.:
267.10
SMILES:
Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Structure:
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