Reaction Details Report a problem with these data
Target
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
Ligand
BDBM380473
Substrate
n/a
Meas. Tech.
High-Throughput Competitive Fluorescence Polarization (FP) Screening Assay
IC50
7.60±n/a nM
Citation
 Walensky, LD Inhibition of MCL-1 and/or BFL-1/A1 US Patent  US9926306 Publication Date 3/27/2018 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
Synonyms:
Bcl-2-related protein EAT/mcl1 | MCL1_MOUSE | Mcl-1 | Mcl1
Type:
Developmental protein
Mol. Mass.:
35215.08
Organism:
Mus musculus (Mouse)
Description:
n/a
Residue:
331
Sequence:
MFGLRRNAVIGLNLYCGGASLGAGGGSPAGARLVAEEAKARREGGGEAALLPGARVVARPPPVGAEDPDVTASAERRLHKSPGLLAVPPEEMAASAAAAIVSPEEELDGCEPEAIGKRPAVLPLLERVSEAAKSSGADGSLPSTPPPPEEEEDDLYRQSLEIISRYLREQATGSKDSKPLGEAGAAGRRALETLRRVGDGVQRNHETAFQGMLRKLDIKNEGDVKSFSRVMVHVFKDGVTNWGRIVTLISFGAFVAKHLKSVNQESFIEPLAETITDVLVRTKRDWLVKQRGWDGFVEFFHVQDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM380473
Synonyms:
US9926306, ID 183-85
Type:
Small organic molecule
Emp. Form.:
C20H27N3O3S
Mol. Mass.:
389.512
SMILES:
COc1cc(\C=N\n2c(C)cs\c2=N/C2CCCCC2)cc(OC)c1OC
Structure:
Search PDB for entries with ligand similarity: