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Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM12357
Substrate
BDBM21974
Meas. Tech.
Enzyme Inhibition Assay
Citation
 Kumar, S; Jaller, D; Patel, B; LaLonde, JM; DuHadaway, JB; Malachowski, WP; Prendergast, GC; Muller, AJ Structure based development of phenylimidazole-derived inhibitors of indoleamine 2,3-dioxygenase. J Med Chem 51:4968-77 (2008) [PubMed]  Article 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
IDO-1 | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine-pyrrole 2,3-dioxygenase | I23O1_HUMAN | IDO1 | IDO | INDO | Indoleamine 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Human
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM12357
Synonyms:
CHEMBL178516 | US8609708, 14 | 3-(1H-imidazol-4-yl)pyridine | US8609708,14 | JMC514968 Compound 7 | nicotine 3-heteroaromatic analogue 10
Type:
Small organic molecule
Emp. Form.:
C8H7N3
Mol. Mass.:
145.06
SMILES:
c1nc(c[nH]1)-c1cccnc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM21974
Synonyms:
(2S)-2-amino-3-(1H-indol-3-yl)propanoic acid | CHEMBL54976 | L-tryptophan | US9138393, L-Tryptophan | US9144538, L-Tryptophan | US11021454, Compound L-trp
Type:
Amino Acid
Emp. Form.:
C11H12N2O2
Mol. Mass.:
204.09
SMILES:
c1ccc2c(c1)c(c[nH]2)C[C@@H](C(=O)O)N
Structure:
Search PDB for entries with ligand similarity: