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Target
Tyrosine-protein phosphatase non-receptor type 11 [205-593]
Ligand
BDBM25127
Substrate
BDBM13432
Meas. Tech.
Inhibition of PTP Activity
pH
6.0000±n/a
Temperature
303.1500±n/a K
IC50
450±n/a nM
Citation
 Dawson, MI; Xia, Z; Jiang, T; Ye, M; Fontana, JA; Farhana, L; Patel, B; Xue, LP; Bhuiyan, M; Pellicciari, R; Macchiarulo, A; Nuti, R; Zhang, XK; Han, YH; Tautz, L; Hobbs, PD; Jong, L; Waleh, N; Chao, WR; Feng, GS; Pang, Y; Su, Y Adamantyl-substituted retinoid-derived molecules that interact with the orphan nuclear receptor small heterodimer partner: effects of replacing the 1-adamantyl or hydroxyl group on inhibition of cancer cell growth, induction of cancer cell apoptosis, and inhibition of SRC homology 2 domain-containi J Med Chem 51:5650-62 (2008) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11 [205-593]
Synonyms:
PTN11_HUMAN | PTPN11 | PTP2C | SHPTP2 | PTP-1D | PTP-2C | SH-PTP3 | Shp2 | Protein-Tyrosine Phosphatase SHP-2
Type:
Protein phosphatase
Mol. Mass.:
44924.47
Organism:
Human
Description:
Human recombinant GST-fusion SHP-2 (205-593).
Residue:
389
Sequence:
TLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQALLQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQ
  
Inhibitor
Name:
BDBM25127
Synonyms:
(2E)-3-{3-chloro-4-[3-(3,3-dimethylbut-1-yn-1-yl)-4-hydroxyphenyl]phenyl}prop-2-enoic acid | 3-Cl-AHPC analogue, 6
Type:
Small organic molecule
Emp. Form.:
C21H19ClO3
Mol. Mass.:
354.10
SMILES:
CC(C)(C)C#Cc1cc(ccc1O)-c1ccc(\C=C\C(O)=O)cc1Cl
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM13432
Synonyms:
6,8-difluoro-4-methylumbelliferyl phosphate | [(6,8-difluoro-4-methyl-2-oxo-2H-chromen-7-yl)oxy]phosphonic acid | DiFMUP
Type:
Small organic molecule
Emp. Form.:
C10H7F2O6P
Mol. Mass.:
291.99
SMILES:
Cc1cc(=O)oc2c(F)c(OP(O)(O)=O)c(F)cc12
Structure:
Search PDB for entries with ligand similarity: