Target
Beta-1 adrenergic receptor
Ligand
BDBM25765
Substrate
BDBM25747
Meas. Tech.
3H-CGP 12177 Whole Cell Binding Assay
pH
7.4±n/a
Temperature
310.15±n/a K
Kd
3.1±.3 nM
Citation
 Baker, JG The selectivity of beta-adrenoceptor antagonists at the human beta1, beta2 and beta3 adrenoceptors. Br J Pharmacol 144:317-22 (2005) [PubMed]  Article 
Target
Name:
Beta-1 adrenergic receptor
Synonyms:
ADRB1 | ADRB1R | ADRB1_HUMAN | B1AR | Beta-1 adrenoceptor | Beta-1 adrenoreceptor | adrenergic Beta1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
51338.40
Organism:
Human
Description:
P08588
Residue:
477
Sequence:
MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQGLLCCARRAARRRHATHGDRPRASGCLARPGPPPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV
  
Inhibitor
Name:
BDBM25765
Synonyms:
Bupranolol | KL 255 | Ophtorenin | tert-butyl[3-(2-chloro-5-methylphenoxy)-2-hydroxypropyl]amine
Type:
Small organic molecule
Emp. Form.:
C14H22ClNO2
Mol. Mass.:
271.783
SMILES:
Cc1ccc(Cl)c(OCC(O)CNC(C)(C)C)c1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM25747
Synonyms:
4-[3-(tert-butylamino)-2-hydroxypropoxy]-2,3-dihydro-1H-1,3-benzodiazol-2-one hydrochloride | CGP 12177 | CGP-12177 | CGP12177 | [3H]CGP 12177
Type:
radiolabeled ligand
Emp. Form.:
C14H21N3O3
Mol. Mass.:
279.3348
SMILES:
CC(C)(C)NCC(O)COc1cccc2[nH]c(=O)[nH]c12
Structure:
Search PDB for entries with ligand similarity: