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Target
Sodium-dependent serotonin transporter
Ligand
BDBM25869
Substrate
BDBM25870
Meas. Tech.
SERT In Vitro Binding Assay
pH
7.7±n/a
Temperature
295.15±n/a K
IC50
33±n/a nM
Citation
 Jaro&ngrave;czyk, M; Chilmonczyk, Z; Mazurek, AP; Nowak, G; Ravna, AW; Kristiansen, K; Sylte, I The molecular interactions of buspirone analogues with the serotonin transporter. Bioorg Med Chem 16:9283-94 (2008) [PubMed]  Article 
Target
Name:
Sodium-dependent serotonin transporter
Synonyms:
5-HT Transporter | 5-HTT | 5HT transporter | 5HTT | Anandamid membrane transporter, AMT | Anandamide membrane transporter, AMT | Monoamine transporters; Norepinephrine & serotonin | SC6A4_RAT | Slc6a4 | Sodium-dependent serotonin transporter | Sodium-dependent serotonin transporter (SERT) | imipramine receptor
Type:
Multi-pass membrane protein
Mol. Mass.:
70168.43
Organism:
Rattus norvegicus (rat)
Description:
P31652
Residue:
630
Sequence:
METTPLNSQKVLSECKDREDCQENGVLQKGVPTTADRAEPSQISNGYSAVPSTSAGDEASHSIPAATTTLVAEIRQGERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIIAWALYYLISSLTDRLPWTSCTNSWNTGNCTNYFAQDNITWTLHSTSPAEEFYLRHVLQIHQSKGLQDLGTISWQLTLCIVLIFTVIYFSIWKGVKTSGKVVWVTATFPYIVLSVLLVRGATLPGAWRGVVFYLKPNWQKLLETGVWVDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKRREWFVLIVVITCVLGSLLTLTSGGAYVVTLLEEYATGPAVLTVALIEAVAVSWFYGITQFCSDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPHWSIVLGYCIGMSSVICIPTYIIYRLISTPGTLKERIIKSITPETPTEIPCGDIRMNAV
  
Inhibitor
Name:
BDBM25869
Synonyms:
2-{4-[2-methyl-4-(quinolin-2-yl)piperazin-1-yl]butyl}-2,3-dihydro-1H-isoindole-1,3-dione | buspirone analogue, 1
Type:
Small organic molecule
Emp. Form.:
C26H28N4O2
Mol. Mass.:
428.5261
SMILES:
CC1CN(CCN1CCCCN1C(=O)c2ccccc2C1=O)c1ccc2ccccc2n1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM25870
Synonyms:
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile | CHEMBL549 | CITALOPRAM | CITALOPRAM HYDROBROMIDE | Escitalopram | [3H]Citalopram | [3H]Cytalopram | [3H]Escitalopram | [3H]Lexapro
Type:
radiolabeled ligand
Emp. Form.:
C20H21FN2O
Mol. Mass.:
324.3919
SMILES:
CN(C)CCCC1(OCc2cc(ccc12)C#N)c1ccc(F)cc1
Structure:
Search PDB for entries with ligand similarity: