Reaction Details Report a problem with these data
Target
Carbonic anhydrase 6
Ligand
BDBM13058
Substrate
BDBM10856
Meas. Tech.
CA Inhibition Assay
Ki
653±n/a nM
Citation
 Temperini, C; Innocenti, A; Scozzafava, A; Supuran, CT Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies. Bioorg Med Chem Lett 18:4282-6 (2008) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 6
Synonyms:
Carbonic anhydrase VI (CA VI) | Carbonic anhydrase 6 (CA VI) | Carbonate dehydratase VI | Carbonic anhydrase 6 | Salivary carbonic anhydrase | Carbonic Anhydrase VI | CA-VI | Secreted carbonic anhydrase | CAH6_HUMAN | CA6 | Carbonic anhydrase | Carbonic anhydrase 6 (CA-VI)
Type:
Enzyme
Mol. Mass.:
35371.40
Organism:
Human
Description:
P23280
Residue:
308
Sequence:
MRALVLLLSLFLLGGQAQHVSDWTYSEGALDEAHWPQHYPACGGQRQSPINLQRTKVRYNPSLKGLNMTGYETQAGEFPMVNNGHTVQISLPSTMRMTVADGTVYIAQQMHFHWGGASSEISGSEHTVDGIRHVIEIHIVHYNSKYKSYDIAQDAPDGLAVLAAFVEVKNYPENTYYSNFISHLANIKYPGQRTTLTGLDVQDMLPRNLQHYYTYHGSLTTPPCTENVHWFVLADFVKLSRTQVWKLENSLLDHRNKTIHNDYRRTQPLNHRVVESNFPNQEYTLGSEFQFYLHKIEEILDYLRRALN
  
Inhibitor
Name:
BDBM13058
Synonyms:
6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c]chromen-3-yl sulfamate | CMT | CHEMBL286738 | STX64 | {9-oxo-8-oxatricyclo[8.5.0.0^{2,7}]pentadeca-1(10),2(7),3,5-tetraen-5-yl} sulfamate | 667COUMATE | BN83495 | 667-COUMATE
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM10856
Synonyms:
methanedione | Carbon Dioxide
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: