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Target
Phosphodiesterase
Ligand
BDBM384821
Substrate
n/a
Meas. Tech.
PDE2 Assay B
Ki
0.110±n/a nM
Citation
 Shen, D; Wang, D; Qian, X; Harper, B; Yang, M; Bo, Y Pyrimidinone amide compounds as PDE2 inhibitors US Patent  US10285989 Publication Date 5/14/2019 
Target
Name:
Phosphodiesterase
Synonyms:
PDE2A3 | Phosphodiesterase A3 (PDE2A3)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
105547.91
Organism:
Macaca mulatta (Rhesus macaque)
Description:
n/a
Residue:
941
Sequence:
MGQACGHSILCRSQQYPAARPAEPRGQQVFLKPDEPPPPPQPCADSLQDALLSLGSVIDISGLQRAVKEALSAVLPRVETVYTYLLDGESRLVCEDPPHELPQEGKVWEAIISQKRLGCNGLGLSDLPGKPLARLVAPLAPHTQVLVIPLVDKEAGAVAAVILVHCGQLSDNEEWSLQAVEKHTLVALRRVQALQQRRPSEAPQAVQNPPEGAVEDQKGGAAYTDRDRKILQLCGELYDLDASSLQLKVLQYLQQETRASRCCLLLVSEDSLQLSCKVMGDKVLGEEISFPLTGCLGQVVEDKKSIQLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDQDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDESTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPEAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDEEYEVPDLDGTGAPINGCCSLDAE
  
Inhibitor
Name:
BDBM384821
Synonyms:
2-(dimethylamino)-N-{(1R)-1-[2- fluoro-4-(trifluoromethyl)phenyl]-2,2- dimethylpropyl}-6-oxo-1,6- dihydropyrimidine-4-carboxamide | US10285989, Example 37
Type:
Small organic molecule
Emp. Form.:
C19H22F4N4O2
Mol. Mass.:
414.3972
SMILES:
CN(C)c1nc(cc(=O)[nH]1)C(=O)N[C@@H](c1ccc(cc1F)C(F)(F)F)C(C)(C)C |r|
Structure:
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