Target
Proto-oncogene tyrosine-protein kinase LCK
Ligand
BDBM25980
Substrate
Biotinylated Peptide Substrate
Meas. Tech.
Time Resolved Fluorescence Resonance Energy Transfer Assay
pH
7.4±n/a
Temperature
295.15±n/a K
Ki
>5400±n/a nM
IC50
>16000±n/a nM
Citation
 Angell, RMBamborough, PCleasby, ACockerill, SGJones, KLMooney, CJSomers, DOWalker, AL Biphenyl amide p38 kinase inhibitors 1: Discovery and binding mode. Bioorg Med Chem Lett 18:318-23 (2008) [PubMed]  Article
Target
Name:
Proto-oncogene tyrosine-protein kinase LCK
Synonyms:
LSK | Lck | Lymphocyte cell-specific protein-tyrosine kinase | Proto-oncogene tyrosine-protein kinase LCK | Tyrosine-protein kinase LCK | p56-LCK
Type:
PROTEIN
Mol. Mass.:
57927.84
Organism:
Mus musculus
Description:
ChEMBL_806408
Residue:
509
Sequence:
MGCVCSSNPEDDWMENIDVCENCHYPIVPLDSKISLPIRNGSEVRDPLVTYEGSLPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHDLVRHYTNASDGLCTKLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHPRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLNVNKLLDMAAQIAEGMAFIEEQNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYHLMMLCWKERPEDRPTFDYLRSVLDDFFTATEGQYQPQP
  
Inhibitor
Name:
BDBM25980
Synonyms:
BMCL18324 Compound 3 | CHEMBL270164 | N-(3-cyanophenyl)-4-[2-methyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]benzamide | biphenyl amide, 3
Type:
Small organic molecule
Emp. Form.:
C24H18N4O2
Mol. Mass.:
394.4253
SMILES:
Cc1nnc(o1)-c1ccc(C)c(c1)-c1ccc(cc1)C(=O)Nc1cccc(c1)C#N
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Biotinylated Peptide Substrate
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
1622.70
Organism:
n/a
Description:
n/a
Residue:
13
Sequence:
ITINEEEEYFELV