Target
Proto-oncogene tyrosine-protein kinase LCK
Ligand
BDBM26180
Substrate
Biotinylated Peptide Substrate
Meas. Tech.
Time Resolved Fluorescence Resonance Energy Transfer Assay
IC50
12±n/a nM
Citation
 Bamborough, PAngell, RMBhamra, IBrown, DBull, JChristopher, JACooper, AWFazal, LHGiordano, IHind, LPatel, VKRanshaw, LESims, MJSkone, PASmith, KJVickerstaff, EWashington, M N-4-Pyrimidinyl-1H-indazol-4-amine inhibitors of Lck: indazoles as phenol isosteres with improved pharmacokinetics. Bioorg Med Chem Lett 17:4363-8 (2007) [PubMed]  Article 
Target
Name:
Proto-oncogene tyrosine-protein kinase LCK
Synonyms:
LCK_MOUSE | LSK | Lck | Lsk-t | Lymphocyte cell-specific protein-tyrosine kinase | Proto-oncogene tyrosine-protein kinase LCK | Tyrosine-protein kinase LCK | p56-LCK
Type:
PROTEIN
Mol. Mass.:
57927.84
Organism:
Mus musculus
Description:
ChEMBL_806408
Residue:
509
Sequence:
MGCVCSSNPEDDWMENIDVCENCHYPIVPLDSKISLPIRNGSEVRDPLVTYEGSLPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHDLVRHYTNASDGLCTKLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHPRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLNVNKLLDMAAQIAEGMAFIEEQNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYHLMMLCWKERPEDRPTFDYLRSVLDDFFTATEGQYQPQP
  
Inhibitor
Name:
BDBM26180
Synonyms:
2,4-dianilino pyrimidine, 37 | 3-({4-[(5-methyl-1H-indazol-4-yl)amino]pyrimidin-2-yl}amino)benzamide
Type:
Small organic molecule
Emp. Form.:
C19H17N7O
Mol. Mass.:
359.3846
SMILES:
Cc1ccc2[nH]ncc2c1Nc1ccnc(Nc2cccc(c2)C(N)=O)n1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Biotinylated Peptide Substrate
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
1622.70
Organism:
n/a
Description:
n/a
Residue:
13
Sequence:
ITINEEEEYFELV