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Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM387591
Substrate
n/a
Meas. Tech.
In-vitro IDO1 Enzyme (Indoleamine 2,3-dioxygenase) Assay
IC50
<200±n/a nM
Citation
 Banerjee, M; Middya, S; Shrivastava, R; Raina, S; Surya, A; Yadav, DB; Yadav, VK; Kapoor, KK; Venkatesan, A; Smith, RA; Thompson, SK Inhibitors of the kynurenine pathway US Patent  US10294212 Publication Date 5/21/2019 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM387591
Synonyms:
2-Amino-3- ((4-fluoro-3- (trifluoro- methyl)phenyl) amino)furo [2,3-c]pyridine- 7-carbonitrile | US10294212, No. 183
Type:
Small organic molecule
Emp. Form.:
C15H8F4N4O
Mol. Mass.:
336.2438
SMILES:
Nc1oc2c(nccc2c1Nc1ccc(F)c(c1)C(F)(F)F)C#N
Structure:
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