Reaction Details Report a problem with these data
Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM387625
Substrate
n/a
Meas. Tech.
In-vitro IDO1 Enzyme (Indoleamine 2,3-dioxygenase) Assay
IC50
<200±n/a nM
Citation
 Banerjee, M; Middya, S; Shrivastava, R; Raina, S; Surya, A; Yadav, DB; Yadav, VK; Kapoor, KK; Venkatesan, A; Smith, RA; Thompson, SK Inhibitors of the kynurenine pathway US Patent  US10294212 Publication Date 5/21/2019 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM387625
Synonyms:
N3-(4- fluorophenyl)- 7-(2- methylpyridin- 4-yl)furo[2,3- c]pyridine-2,3- diamine | US10294212, No. 208
Type:
Small organic molecule
Emp. Form.:
C19H15FN4O
Mol. Mass.:
334.347
SMILES:
Cc1cc(ccn1)-c1nccc2c(Nc3ccc(F)cc3)c(N)oc12
Structure:
Search PDB for entries with ligand similarity: