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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM26663
Substrate
GST-BAD
Meas. Tech.
Solid-Phase ELISA Kinase Assay
pH
7.0000±n/a
Temperature
303.1500±n/a K
IC50
12500±n/a nM
Citation
 Holder, S; Zemskova, M; Zhang, C; Tabrizizad, M; Bremer, R; Neidigh, JW; Lilly, MB Characterization of a potent and selective small-molecule inhibitor of the PIM1 kinase. Mol Cancer Ther 6:163-72 (2007) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
Serine/threonine-protein kinase PIM | PIM-1 Kinase | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1) | PIM1_HUMAN | PIM1
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Human
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM26663
Synonyms:
(2S)-5,7-dihydroxy-8-(3-methylbut-2-en-1-yl)-2-phenyl-3,4-dihydro-2H-1-benzopyran-4-one | (S)-5,7-dihydroxy-8-(3-methylbut-2-ene)flavanone
Type:
Flavonoid
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Bcl2-associated agonist of cell death
Synonyms:
GST fusion protein of Bcl2 antagonist of cell death | BAD_MOUSE | Bad | Bbc6 | GST-BAD
Type:
Other Protein Type
Mol. Mass.:
22084.58
Organism:
Mouse
Description:
n/a
Residue:
204
Sequence:
MGTPKQPSLAPAHALGLRKSDPGIRSLGSDAGGRRWRPAAQSMFQIPEFEPSEQEDASATDRGLGPSLTEDQPGPYLAPGLLGSNIHQQGRAATNSHHGGAGAMETRSRHSSYPAGTEEDEGMEEELSPFRGRSRSAPPNLWAAQRYGRELRRMSDEFEGSFKGLPRPKSAGTATQMRQSAGWTRIIQSWWDRNLGKGGSTPSQ