Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase Lyn
Ligand
BDBM13216
Substrate
n/a
Meas. Tech.
Kinase Screening Assay
IC50
<10.00±n/a nM
Citation
 Unciti-Broceta, A; Fraser, C; O. Carragher, N Compounds US Patent  US10294227 Publication Date 5/21/2019 
Target
Name:
Tyrosine-protein kinase Lyn
Synonyms:
Lck/Yes-related novel protein tyrosine kinase | Tyrosine-protein kinase Lyn (LYN) | V-yes-1 Yamaguchi sarcoma viral related oncogene homolog | p53Lyn | p56Lyn | LYN_HUMAN | LYN | JTK8
Type:
Protein
Mol. Mass.:
58575.92
Organism:
Human
Description:
P07948
Residue:
512
Sequence:
MGCIKSKGKDSLSDDGVDLKTQPVRNTERTIYVRDPTSNKQQRPVPESQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFYTATEGQYQQQP
  
Inhibitor
Name:
BDBM13216
Synonyms:
N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide | cid_3062316 | N-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide | CHEMBL1421 | DASATINIB | BMS-354825 | US10294227, Code Dasatinib | med.21724, Compound Dasatinib | US20230348453, Compound A8
Type:
Small organic molecule
Emp. Form.:
C22H26ClN7O2S
Mol. Mass.:
487.16
SMILES:
Cc1cccc(c1NC(=O)c2cnc(s2)Nc3cc(nc(n3)C)N4CCN(CC4)CCO)Cl
Structure:
Search PDB for entries with ligand similarity: