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Target
Pantetheinase
Ligand
BDBM395062
Substrate
n/a
Meas. Tech.
Human Vanin-1 Enzyme Assay 3
IC50
1.20±n/a nM
Citation
 Casimiro-Garcia, A; Condon, JS; Flick, AC; Gopalsamy, A; Kirincich, SJ; Mathias, JP; Strobach, JW; Xiang, JS; Xing, LH; Wang, X Heterocyclic compounds as inhibitors of Vanin-1 enzyme US Patent  US10308615 Publication Date 6/4/2019 
Target
Name:
Pantetheinase
Synonyms:
VNN1_HUMAN | VNN1 | Pantetheine hydrolase | Tiff66 | Vanin-1 | Vascular non-inflammatory molecule 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57002.46
Organism:
Human
Description:
O95497
Residue:
513
Sequence:
MTTQLPAYVAILLFYVSRASCQDTFTAAVYEHAAILPNATLTPVSREEALALMNRNLDILEGAITSAADQGAHIIVTPEDAIYGWNFNRDSLYPYLEDIPDPEVNWIPCNNRNRFGQTPVQERLSCLAKNNSIYVVANIGDKKPCDTSDPQCPPDGRYQYNTDVVFDSQGKLVARYHKQNLFMGENQFNVPKEPEIVTFNTTFGSFGIFTCFDILFHDPAVTLVKDFHVDTIVFPTAWMNVLPHLSAVEFHSAWAMGMRVNFLASNIHYPSKKMTGSGIYAPNSSRAFHYDMKTEEGKLLLSQLDSHPSHSAVVNWTSYASSIEALSSGNKEFKGTVFFDEFTFVKLTGVAGNYTVCQKDLCCHLSYKMSENIPNEVYALGAFDGLHTVEGRYYLQICTLLKCKTTNLNTCGDSAETASTRFEMFSLSGTFGTQYVFPEVLLSENQLAPGEFQVSTDGRLFSLKPTSGPVLTVTLFGRLYEKDWASNASSGLTAQARIIMLIVIAPIVCSLSW
  
Inhibitor
Name:
BDBM395062
Synonyms:
US10308615, Example 73 | (2-{[(6- methylpyridin-3- yl)methyl]amino} pyrimidin-5-yl)[3- (trifluoromethyl) phenyl]methanone
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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