Reaction Details Report a problem with these data
Target
Diacylglycerol O-acyltransferase 1
Ligand
BDBM395361
Substrate
n/a
Meas. Tech.
Measurement of DGAT1 Inhibitory Activity
IC50
1.50±n/a nM
Citation
 Saruta, K; Hayashi, N; Sakurai, O; Sawamoto, H; Ooboki, E Aromatic heterocyclic compound US Patent  US10308636 Publication Date 6/4/2019 
Target
Name:
Diacylglycerol O-acyltransferase 1
Synonyms:
Diacylglycerol Acyltransferase (DGAT1) | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | ACAT-related gene product 1 | Diglyceride acyltransferase | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | DGAT1_HUMAN | DGAT1 | AGRP1 | DGAT
Type:
Protein
Mol. Mass.:
55297.82
Organism:
Human
Description:
O75907
Residue:
488
Sequence:
MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVGSGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQVVSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPAAVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHTVSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWMVPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREFYRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVSVPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLNYEAPAAEA
  
Inhibitor
Name:
BDBM395361
Synonyms:
US10308636, Example 45-1
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
CCOC(=O)c1cccc(OCC2CCN(CC2)c2ccc(cc2)-c2nc(cn2COCC[Si](C)(C)C)C(F)(F)F)c1C
Structure:
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