Target
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1
Ligand
BDBM395799
Substrate
n/a
Meas. Tech.
CDK Assay
IC50
<10±n/a nM
Citation
 Cheng, PCao, W Preparation and use of kinase inhibitor US Patent  US10308654 Publication Date 6/4/2019 
Target
Name:
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1
Synonyms:
CDK4/CyclinD1 | cdk4
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Cyclin-dependent kinase 4
Synonyms:
CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3
Type:
Enzyme Subunit
Mol. Mass.:
33731.96
Organism:
Homo sapiens (Human)
Description:
P11802
Residue:
303
Sequence:
MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE
  
Component 2
Name:
G1/S-specific cyclin-D1
Synonyms:
CCND1_MOUSE | Ccnd1 | Cyclin D1 | Cyl-1
Type:
Enzyme Subunit
Mol. Mass.:
33418.84
Organism:
Mus musculus (mouse)
Description:
n/a
Residue:
295
Sequence:
MEHQLLCCEVETIRRAYPDTNLLNDRVLRAMLKTEETCAPSVSYFKCVQKEIVPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPLKKSRLQLLGATCMFVASKMKETIPLTAEKLCIYTDNSIRPEELLQMELLLVNKLKWNLAAMTPHDFIEHFLSKMPEADENKQTIRKHAQTFVALCATDVKFISNPPSMVAAGSVVAAMQGLNLGSPNNFLSCYRTTHFLSRVIKCDPDCLRACQEQIEALLESSLRQAQQNVDPKATEEEGEVEEEAGLACTPTDVRDVDI
  
Inhibitor
Name:
BDBM395799
Synonyms:
US10308654, Example 27
Type:
Small organic molecule
Emp. Form.:
C25H35N9O
Mol. Mass.:
477.6051
SMILES:
C[C@H]1CN(C[C@@H](C)N1)c1ccc(Nc2ncc3cc(C(=O)N(C)C)n(N4CCCCC4)c3n2)nc1 |r|
Structure:
Search PDB for entries with ligand similarity: