Target
TGF-beta receptor type-1 [T204D]
Ligand
BDBM396761
Substrate
n/a
Meas. Tech.
Biological Assay
IC50
4.00±n/a nM
Citation
 Ding, PGelman, MKinsella, TSingh, RBhamidipati, SVelaparthi, UBorzilleri, RMRahaman, HWarrier, JS GDF-8 inhibitors US Patent  US9981944 Publication Date 5/29/2018 
Target
Name:
TGF-beta receptor type-1 [T204D]
Synonyms:
ALK5 | SKR4 | TGF-beta receptor type-1 (T204D) | TGF-betaR1 T204D | TGFBR1 | TGFBR1T204D | TGFR-1 (T204D) | TGFR1_HUMAN
Type:
n/a
Mol. Mass.:
55981.22
Organism:
Homo sapiens (Human)
Description:
P36897[T204D]
Residue:
503
Sequence:
MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARDIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
  
Inhibitor
Name:
BDBM396761
Synonyms:
6-(6'-cyclopropyl-[2,2'-bipyridin]-3- yl)pyrido[3,2-d]pyrimidin-4-amine | US9981944, Example 106
Type:
Small organic molecule
Emp. Form.:
C20H16N6
Mol. Mass.:
340.3812
SMILES:
Nc1ncnc2ccc(nc12)-c1cccnc1-c1cccc(n1)C1CC1
Structure:
Search PDB for entries with ligand similarity: