Reaction Details Report a problem with these data
Target
TGF-beta receptor type-1 [T204D]
Ligand
BDBM396775
Substrate
n/a
Meas. Tech.
Biological Assay
IC50
6.00±n/a nM
Citation
 Ding, P; Gelman, M; Kinsella, T; Singh, R; Bhamidipati, S; Velaparthi, U; Borzilleri, RM; Rahaman, H; Warrier, JS GDF-8 inhibitors US Patent  US9981944 Publication Date 5/29/2018 
Target
Name:
TGF-beta receptor type-1 [T204D]
Synonyms:
ALK5 | SKR4 | TGF-beta receptor type-1 (T204D) | TGF-betaR1 T204D | TGFBR1 | TGFBR1T204D | TGFR-1 (T204D) | TGFR1_HUMAN
Type:
n/a
Mol. Mass.:
55981.22
Organism:
Homo sapiens (Human)
Description:
P36897[T204D]
Residue:
503
Sequence:
MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARDIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
  
Inhibitor
Name:
BDBM396775
Synonyms:
5-(6'-methyl-[2,2'-bipyridin]-3- yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide | US9981944, Example 120
Type:
Small organic molecule
Emp. Form.:
C18H14N6O
Mol. Mass.:
330.3434
SMILES:
Cc1cccc(n1)-c1ncccc1-c1ccn2ncc(C(N)=O)c2n1
Structure:
Search PDB for entries with ligand similarity: